The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pleuritic chest pain
Publications
Recurrent acute nitrofurantoin-induced pulmonary toxicity.
Pharmacotherapy. 2006;26(5):713-8
Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
The Annals of pharmacotherapy. 2004;38(4):612-6
Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.
Obstetrical & gynecological survey. 1996;51(6):367-70
Hospitalizations for pulmonary reactions following nitrofurantoin use.
Chest. 1989;96(3):512-5