The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Erjavec Z, Woolthuis GM, de Vries-Hospers HG, Sluiter WJ, Daenen SM, de Pauw B, Halie MR

Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1997 May;16;364-8 — 1997 May — 364-8

Dubois J, Bartter T, Gryn J, Pratter MR

The physiologic effects of inhaled amphotericin B.

Chest 1995 Sep;108;750-3 — 1995 Sep — 750-3

Spitzer TR, Creger RJ, Fox RM, Lazarus HM

Rapid infusion amphotericin B: effective and well-tolerated therapy for neutropenic fever.

Pharmatherapeutica 1989;5;305-11 — 1989 — 305-11