The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Davis JW, Jones LS

Pleural effusion: An uncommon manifestation of nitrofurantoin-induced pulmonary injury.

Respiratory medicine case reports 2016;19;65-7 — 2016 — 65-7

Hardak E, Berger G, Krivoy N, Solomonov A, Yigla M

Nitrofurantoin pulmonary toxicity: neglected threat.

Current drug safety 2010 Apr;5;125-8 — 2010 Apr — 125-8

Kalomenidis I, Light RW

Eosinophilic pleural effusions.

Current opinion in pulmonary medicine 2003 Jul;9;254-60 — 2003 Jul — 254-60

Strauss WG, Griffin LM

Nitrofurantoin pneumonia.

JAMA 1967 Mar 06;199;765-6 — 1967 Mar 06 — 765-6

Geller M, Flaherty DK, Dickie HA, Reed CE

Lymphopenia in acute nitrofurantoin pleuropulmonary reactions.

The Journal of allergy and clinical immunology 1977 Jun;59;445-8 — 1977 Jun — 445-8