The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Publications

Penn RG, Griffin JP

Adverse reactions to nitrofurantoin in the United Kingdom, Sweden, and Holland.

British medical journal (Clinical research ed.) 1982 May 15;284;1440-2 — 1982 May 15 — 1440-2

Walton CH

Asthma associated with the use of nitrofurantoin.

Canadian Medical Association journal 1966 Jan 01;94;40-1 — 1966 Jan 01 — 40-1

Bayer WL, Dawson RB, Kotin E

Allergic tracheobronchitis due to nitrofurantoin sensitivity. Report of a case.

Diseases of the chest 1965 Oct;48;429-30 — 1965 Oct — 429-30

Morgan LK

Nitrofurantoin pulmonary hypersensitivity.

The Medical journal of Australia 1970 Jul 18;2;136-9 — 1970 Jul 18 — 136-9

Vilaseca Momplet J, Fuentes Otero FJ, Ballester Rodes M, Fort Ros J, Pedro-Botet J

[Asthma and nitrofurantoin].

Revista clinica espanola 1979 Feb 15;152;235-7 — 1979 Feb 15 — 235-7