The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.k

Sarcoid-like granulomatosis (endo-/extrathoracic)

Publications

Ali MS, Franco R, Dhotre D, Rao N

Tumour necrosis factor (TNF) inhibitor-induced isolated pleural granulomas: a rare adverse effect.

BMJ case reports. 2017;2017

Gîlcă GE, Diaconescu S, Bălan GG, Timofte O, Ştefănescu G

Sarcoidosis associated with infliximab therapy in ulcerative colitis: A case report.

Medicine. 2017;96(10):e6156

Daïen CI, Monnier A, Claudepierre P, Constantin A, Eschard JP, Houvenagel E, Samimi M, Pavy S, Pertuiset E, Toussirot E, Combe B, Morel J, Club Rhumatismes et Inflammation (CRI)

Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases.

Rheumatology (Oxford, England). 2009;48(8):883-6