The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
Publications
Nitrofurantoin-induced pulmonary reaction involving respiratory symptoms: case report.
The Canadian journal of hospital pharmacy. 2011;64(5):362-5
Baptista JP, Casanova PC, Sousa JP, Martins PJ, Simões A, Fernandes V, Souto J, Costa JJ, Rebelo A, Carvalho L, Pimentel J
[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].
Revista portuguesa de pneumologia. 2004;10(4):355-64
Adult respiratory distress syndrome associated with acute nitrofurantoin toxicity. Successful treatment with continuous positive airway pressure.
Respiration; international review of thoracic diseases. 1980;39(6):318-22