The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Naureen S, Hart S, Jawad N, Kennan N, Faruqi S

Long term nitrofurantoin induced interstitial lung disease: a case series and literature review.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 2023;40(4):e2023050

O'Bryen J, Hannay G, Gleeson S

Nitrofurantoin-induced pulmonary fibrosis.

Australian journal of general practice. 2022;51(3):149-151

Speirs TP, Tuffin N, Mundy-Baird F, Sakota H, Mulholland S, Westlake M, Lyon M, Medford AR, Sharp C, Darby M, Albur M, Keeley F, Burden H, Kenward C, Jonas E, Barratt S, Adamali HI

Long-term nitrofurantoin: an analysis of complication awareness, monitoring, and pulmonary injury cases.

BJGP open. 2021;5(6)

Rambaran KA, Seifert CF

Unrecognized Interstitial Lung Disease as a Result of Chronic Nitrofurantoin Use.

Drug safety - case reports. 2016;3(1):13

Mendez JL, Nadrous HF, Hartman TE, Ryu JH

Chronic nitrofurantoin-induced lung disease.

Mayo Clinic proceedings. 2005;80(10):1298-302

ROBINSON BR

PLEUROPULMONARY REACTION TO NITROFURANTOIN.

JAMA. 1964;189:239-40

Sheehan RE, Wells AU, Milne DG, Hansell DM

Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.

Journal of computer assisted tomography. 2000;24(2):259-61

Kristensen D, Andersen M

[Adverse effects of nitrofurantoin--cases reported to the Adverse Drug Reaction Committee during the period 1968-1992].

Ugeskrift for laeger. 1995;157(6):761-3

Holmberg L, Boman G, Böttiger LE, Eriksson B, Spross R, Wessling A

Adverse reactions to nitrofurantoin. Analysis of 921 reports.

The American journal of medicine. 1980;69(5):733-8

Willcox PA, Maze SS, Sandler M, Benatar SR

Pulmonary fibrosis following long-term nitrofurantoin therapy.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1982;61(19):714-7

Lübbers P

[Chronic interstitial pneumonia with pulmonary fibrosis following long-term nitrofurantoin therapy].

Medizinische Klinik. 1971;66(22):818-22

Israel KS, Brashear RE, Sharma HM, Yum MN, Glover JL

Pulmonary fibrosis and nitrofurantoin.

The American review of respiratory disease. 1973;108(2):353-6

Sovijärvi AR, Lemola M, Stenius B, Idänpään-Heikkilä J

Nitrofurantoin-induced acute, subacute and chronic pulmonary reactions.

Scandinavian journal of respiratory diseases. 1977;58(1):41-50

Winterbauer RH, Hammar SP, Hallman KO, Hays JE, Pardee NE, Morgan EH, Allen JD, Moores KD, Bush W, Walker JH

Diffuse interstitial pneumonitis. Clinicopathologic correlations in 20 patients treated with prednisone/azathioprine.

The American journal of medicine. 1978;65(4):661-72