The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Kabbara WK, Kordahi MC

Nitrofurantoin-induced pulmonary toxicity: A case report and review of the literature.

Journal of infection and public health. 2015;8(4):309-13

Leão RN, Barreto P, Leão RR, Ribeiro JV

Nitrofurantoin: cause of DRESS syndrome.

BMJ case reports. 2013;2013

Milić R, Plavec G, Tufegdzić I, Tomić I, Sarac S, Loncarević O

Nitrofurantoin-induced immune-mediated lung and liver disease.

Vojnosanitetski pregled. 2012;69(6):536-40

Martins RR, Marchiori E, Viana SL, Grillo Júnior LS, Capelozzi VL, Valença LM

Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2008;34(3):181-4

Schelhorn J, Höfer L, Syrbe G, Polzer U

[Drug-induced eosinophilic pneumonia].

Der Nervenarzt. 2008;79(6):696-8

Baptista JP, Casanova PC, Sousa JP, Martins PJ, Simões A, Fernandes V, Souto J, Costa JJ, Rebelo A, Carvalho L, Pimentel J

[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].

Revista portuguesa de pneumologia. 2004;10(4):355-64

Magee F, Wright JL, Chan N, Currie W, Karr G, Hogg J, Thurlbeck WM

Two unusual pathological reactions to nitrofurantoin: case reports.

Histopathology. 1986;10(7):701-6