The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Kabbara WK, Kordahi MC

Nitrofurantoin-induced pulmonary toxicity: A case report and review of the literature.

Journal of infection and public health 2015 Jul-Aug;8;309-13 — 2015 Jul-Aug — 309-13

Leão RN, Barreto P, Leão RR, Ribeiro JV

Nitrofurantoin: cause of DRESS syndrome.

BMJ case reports 2013 May 08;2013; — 2013 May 08

Mili? R, Plavec G, Tufegdzi? I, Tomi? I, Sarac S, Loncarevi? O

Nitrofurantoin-induced immune-mediated lung and liver disease.

Vojnosanitetski pregled 2012 Jun;69;536-40 — 2012 Jun — 536-40

Martins RR, Marchiori E, Viana SL, Grillo Júnior LS, Capelozzi VL, Valença LM

Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2008 Mar;34;181-4 — 2008 Mar — 181-4

Schelhorn J, Höfer L, Syrbe G, Polzer U

[Drug-induced eosinophilic pneumonia].

Der Nervenarzt 2008 Jun;79;696-8 — 2008 Jun — 696-8

Baptista JP, Casanova PC, Sousa JP, Martins PJ, Simões A, Fernandes V, Souto J, Costa JJ, Rebelo A, Carvalho L, Pimentel J

[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].

Revista portuguesa de pneumologia 2004 Jul-Aug;10;355-64 — 2004 Jul-Aug — 355-64

Magee F, Wright JL, Chan N, Currie W, Karr G, Hogg J, Thurlbeck WM

Two unusual pathological reactions to nitrofurantoin: case reports.

Histopathology 1986 Jul;10;701-6 — 1986 Jul — 701-6