The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Lourenço EP, Nzwalo H, Sampaio MR, Brito H

Lung caught in Nilutamide treatment.

BMJ case reports 2016 Sep 06;2016; — 2016 Sep 06

Bennett CL, Raisch DW, Sartor O

Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect.

Annals of internal medicine 2002 Oct 01;137;625 — 2002 Oct 01 — 625

Seigneur J, Trechot PF, Hubert J, Lamy P

Pulmonary complications of hormone treatment in prostate carcinoma.

Chest 1988 May;93;1106 — 1988 May — 1106

Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F

Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report.

The American journal of medicine 1992 May;92;563-6 — 1992 May — 563-6

Pfitzenmeyer P, Foucher P, Piard F, Coudert B, Braud ML, Gabez P, Lacroix S, Mabille JP, Camus P

Nilutamide pneumonitis: a report on eight patients.

Thorax 1992 Aug;47;622-7 — 1992 Aug — 622-7