The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.d

Myocarditis (can be fulminant)

Publications

Tan MCC, Ortega-Legaspi JM, Cheng SF, Patton KK

Acute myocarditis following high-dose interleukin-2 treatment.

Journal of cardiology cases 2017 Jan;15;28-31 — 2017 Jan — 28-31

Chow S, Cove-Smith L, Schmitt M, Hawkins R

High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI?

Journal of immunotherapy (Hagerstown, Md. : 1997) 2014 Jun;37;304-8 — 2014 Jun — 304-8