The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Tomlinson J, Tighe M, Johnson S, Stone R, Nicholson AG, Rule S

Interstitial pneumonitis following mitozantrone, chlorambucil and prednisolone (MCP) chemotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain)) 1999;11;184-6 — 1999 — 184-6

Matsukawa Y, Takeuchi J, Aiso M, Hagiwara T, Hayama T, Ohshima T, Horie T, Kitami Y

Interstitial pneumonitis possibly due to mitoxantrone.

Acta haematologica 1993;90;155-8 — 1993 — 155-8

Quigley M, Brada M, Heron C, Horwich A

Severe lung toxicity with a weekly low dose chemotherapy regimen in patients with non-Hodgkin's lymphoma.

Hematological oncology 1988 Oct-Dec;6;319-24 — 1988 Oct-Dec — 319-24