The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LX.b

Lymphoproliferative disease (pulmonary, endobronchial, endothoracic)

Publications

Barakat A, Grover K, Peshin R

Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis.

SpringerPlus 2014;3;751 — 2014 — 751

Connors W, Griffiths C, Patel J, Belletrutti PJ

Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.

BMC gastroenterology 2014 Jul 14;14;127 — 2014 Jul 14 — 127