The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.t

Heart block (bundle branch- or AV-)

Publications

Höjer J, Olsson E

AV block II in a toddler after ingestion of a single tablet fingolimod.

Clinical toxicology (Philadelphia, Pa.) 2014 Jul;52;644 — 2014 Jul — 644

Ward MD, Jones DE, Goldman MD

Overview and safety of fingolimod hydrochloride use in patients with multiple sclerosis.

Expert opinion on drug safety 2014 Jul;13;989-98 — 2014 Jul — 989-98