The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Lawson TM, Amos N, Bulgen D, Williams BD

Minocycline-induced lupus: clinical features and response to rechallenge.

Rheumatology (Oxford, England). 2001;40(3):329-35

Marzo-Ortega H, Misbah S, Emery P

Minocycline induced autoimmune disease in rheumatoid arthritis: a missed diagnosis?

The Journal of rheumatology. 2001;28(2):377-8

Christodoulou CS, Emmanuel P, Ray RA, Good RA, Schnapf BM, Cawkwell GD

Respiratory distress due to minocycline-induced pulmonary lupus.

Chest. 1999;115(5):1471-3

Akin E, Miller LC, Tucker LB

Minocycline-induced lupus in adolescents.

Pediatrics. 1998;101(5):926

Knowles SR, Shapiro L, Shear NH

Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature.

Archives of dermatology. 1996;132(8):934-9

Gough A, Chapman S, Wagstaff K, Emery P, Elias E

Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome.

BMJ (Clinical research ed.). 1996;312(7024):169-72