The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
Publications
Interstitial pneumonia and hepatitis caused by minocycline.
The Netherlands journal of medicine 2004 Feb;62;62-4 — 2004 Feb — 62-4
Bronchiolitis obliterans organizing pneumonia associated with minocycline therapy: a possible cause.
The European respiratory journal 1995 Jun;8;1018-20 — 1995 Jun — 1018-20