The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Jabbal S, Anderson W, Short P, Morrison A, Manoharan A, Lipworth BJ

Cardiopulmonary interactions with beta-blockers and inhaled therapy in COPD.

QJM : monthly journal of the Association of Physicians. 2017;110(12):785-792

Self T, Rogers ML, Mancell J, Soberman JE

Carvedilol therapy after cocaine-induced myocardial infarction in patients with asthma.

The American journal of the medical sciences. 2011;342(1):56-61

Cazzola M, Noschese P, D'Amato M, D'Amato G

Comparison of the effects of single oral doses of nebivolol and celiprolol on airways in patients with mild asthma.

Chest. 2000;118(5):1322-6

Dunn CJ, Lea AP, Wagstaff AJ

Carvedilol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders.

Drugs. 1997;54(1):161-85