The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LV.b

Imaging: Ground-glass opacities (GGO) / shadowing

Publications

Tzilas V, Charokopos A, Kolilekas L, Manali E, Papiris S, Ryu JH, Bouros D

Presenting Features and Clinical Course of Chronic Nitrofurantoin-Induced Lung Toxicity.

Chest 2022 Mar;161;748-752 — 2022 Mar — 748-752

Broughton RA, Wilson HD

Nitrofurantoin pulmonary toxicity in a child.

Pediatric infectious disease 1986 Jul-Aug;5;466-9 — 1986 Jul-Aug — 466-9