The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

A complication of drug overdose

Publications

Afzal MA, Ozgur SS, Tagliaferri AR, Bathobakae L, Shamoon F

Unique Case of Cardiogenic Shock in the Setting of Cumulative Calcium Channel Blocker Toxicity.

Cureus 2023 Mar;15;e36762 — 2023 Mar — e36762

Chaouat A, Kessler R, Weitzenblum E

Pulmonary oedema and pleural effusion in two patients with primary pulmonary hypertension treated with calcium channel blockers.

Heart (British Cardiac Society) 1996 Apr;75;383 — 1996 Apr — 383

Howarth DM, Dawson AH, Smith AJ, Buckley N, Whyte IM

Calcium channel blocking drug overdose: an Australian series.

Human & experimental toxicology 1994 Mar;13;161-6 — 1994 Mar — 161-6