The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Deljou A, Hedrick SJ, Portner ER, Schroeder DR, Hooten WM, Sprung J, Weingarten TN

Pattern of perioperative gabapentinoid use and risk for postoperative naloxone administration.

British journal of anaesthesia 2018 Apr;120;798-806 — 2018 Apr — 798-806

Gabapentin and risk of severe respiratory depression.

Drug and therapeutics bulletin 2018 Jan;56;3-4 — 2018 Jan — 3-4

Ongley D, Hayward AK, Allan C

Severe respiratory depression associated with perioperative opioid-sparing gabapentin use.

Anaesthesia and intensive care 2014 Jan;42;136-7 — 2014 Jan — 136-7

Català Pérez R, Gámez Lechuga M, Martínez-Lage Alvarez M, Antón Albisu A

[Gabapentin-induced central hypoventilation].

Medicina clinica 2007 Apr 07;128;519 — 2007 Apr 07 — 519

Batoon SB, Vela AT, Dave D, Wahid Z, Conetta R, Iakovou C, Banzuela M

Recurrent hypoventilation and respiratory failure during gabapentin therapy.

Journal of the American Geriatrics Society 2001 Apr;49;498 — 2001 Apr — 498