The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.af

Coronary vasospasm - Vasospastic angina

Publications

Charkviani M, Murvelashvili N, Barrera F, Sharma A, Eldin RS, Nabil NUN

Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil.

Case reports in oncological medicine. 2020;2020:4151474

Thapa B, Chahine J, Kadri AN, Gajulapalli R, Angel M

5-Fluorouracil-Associated Coronary Vasospasm in a Patient With Metastatic Adenocarcinoma of the Esophagus.

American journal of therapeutics. 2019;26(5):e664-e668

Sara JD, Kaur J, Khodadadi R, Rehman M, Lobo R, Chakrabarti S, Herrmann J, Lerman A, Grothey A

5-fluorouracil and cardiotoxicity: a review.

Therapeutic advances in medical oncology. 2018;10:1758835918780140

Tsibiribi P, Descotes J, Lombard-Bohas C, Barel C, Bui-Xuan B, Belkhiria M, Tabib A, Timour Q

Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.

Bulletin du cancer. 2006;93(3):E27-30

Kleiman NS, Lehane DE, Geyer CE Jr, Pratt CM, Young JB

Prinzmetal's angina during 5-fluorouracil chemotherapy.

The American journal of medicine. 1987;82(3):566-8