The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Sarzi-Puttini P, Atzeni F, Capsoni F, Lubrano E, Doria A

Drug-induced lupus erythematosus.

Autoimmunity 2005 Nov;38;507-18 — 2005 Nov — 507-18

Vernino SA, Moder KG

68-year-old woman with dyspnea and chest pain.

Mayo Clinic proceedings 1996 May;71;485-8 — 1996 May — 485-8

Harrington TM, Davis DE

Systemic lupus-like syndrome induced by methyldopa therapy.

Chest 1981 Jun;79;696-7 — 1981 Jun — 696-7