The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.e

ARDS - Acute lung injury

Publications

Dhokarh R, Li G, Schmickl CN, Kashyap R, Assudani J, Limper AH, Gajic O

Drug-associated acute lung injury: a population-based cohort study.

Chest 2012 Oct;142;845-850 — 2012 Oct — 845-850

Le Guillou F, Dominique S, Dubruille V, Contentin N, Tilly H, Nouvet G

[Acute respiratory distress syndrome due to pneumonitis following intrathecal methotrexate administration].

Revue des maladies respiratoires 2003 Apr;20;273-7 — 2003 Apr — 273-7

Dai MS, Ho CL, Chen YC, Kao WY, Chao TY

Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.

Annals of hematology 2000 Dec;79;696-9 — 2000 Dec — 696-9