The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Bernstein ML, Sobel DB, Wimmer RS

Noncardiogenic pulmonary edema following injection of methotrexate into the cerebrospinal fluid.

Cancer 1982 Sep 01;50;866-8 — 1982 Sep 01 — 866-8

Lascari AD, Strano AJ, Johnson WW, Collins JG

Methotrexate-induced sudden fatal pulmonary reaction.

Cancer 1977 Oct;40;1393-7 — 1977 Oct — 1393-7