The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.h

Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

Publications

Savilampi J, Omari T, Magnuson A, Ahlstrand R

Effects of remifentanil on pharyngeal swallowing: A double blind randomised cross-over study in healthy volunteers.

European journal of anaesthesiology 2016 09;33;622-30 — 2016 09 — 622-30

Savilampi J, Ahlstrand R, Magnuson A, Geijer H, Wattwil M

Aspiration induced by remifentanil: a double-blind, randomized, crossover study in healthy volunteers.

Anesthesiology 2014 Jul;121;52-8 — 2014 Jul — 52-8