The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
Pleural effusion was not in isolation (PMID 24593234), but instead it was associated with BCG-induced ILD
Publications
Pleural effusion as a late complication of intravesical BCG treatment.
Thorax 2018 04;73;393-394 — 2018 04 — 393-394
BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6.
BMC pulmonary medicine 2014 Mar 05;14;35 — 2014 Mar 05 — 35