The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Virzì F, Giacopelli G, Tutone P, Profera L, Giarratano A, Raineri SM, Tomasello S, Accurso G

Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.

Respiratory medicine case reports 2025;56;102238 — 2025 — 102238

Soentjens P, Delanote M, Van Gompel A

Mefloquine-induced pneumonitis.

Journal of travel medicine 2006 May-Jun;13;172-4 — 2006 May-Jun — 172-4

Drent M

Drug-induced pneumonia associated with hemizygote glucose-6-phosphate-dehydrogenase deficiency.

European journal of haematology 1998 Sep;61;218-20 — 1998 Sep — 218-20