The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.e

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Boyd RE, Brennan PT, Deng JF, Rochester DF, Spyker DA

Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis.

The American journal of medicine 1983 Mar;74;507-12 — 1983 Mar — 507-12

Yamarick W, Walson P, DiTraglia J

Strychnine poisoning in an adolescent.

Journal of toxicology. Clinical toxicology 1992;30;141-8 — 1992 — 141-8