The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cough (lone)
Some studies do suggest there is no statistically signicant increase in the incidence of prevalence for cough with lostartan compared to control arm (PMID 7706699)
Publications
Cough induced by losartan with resolution after substitution with enalapril.
Clinical therapeutics 2008 Mar;30;548-51 — 2008 Mar — 548-51
Losartan-induced cough after lisinopril therapy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2000 May 15;57;996-7 — 2000 May 15 — 996-7
Losartan-induced cough after lisinopril therapy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 1999 May 01;56;914-5 — 1999 May 01 — 914-5
Use of losartan in the treatment of hypertensive patients with a history of cough induced by angiotensin-converting enzyme inhibitors.
Clinical therapeutics 1998 Sep-Oct;20;978-89 — 1998 Sep-Oct — 978-89