The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Opportunistic pulmonary/systemic infections
Publications
Case 9-2020: A 64-Year-Old Man with Shortness of Breath, Cough, and Hypoxemia.
The New England journal of medicine. 2020;382(12):1150-1159
Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome.
Case reports in infectious diseases. 2018;2018:6341680
Opportunistic infections in rheumatoid arthritis patients exposed to biologic therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Rheumatology (Oxford, England). 2018;57(6):997-1001
Baddley JW, Winthrop KL, Chen L, Liu L, Grijalva CG, Delzell E, Beukelman T, Patkar NM, Xie F, Saag KG, Herrinton LJ, Solomon DH, Lewis JD, Curtis JR
Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) study.
Annals of the rheumatic diseases. 2014;73(11):1942-8
Biologic therapy and risk of infection.
Skin therapy letter. 2012;17(4):1-4
Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective.
Current rheumatology reviews. 2011;7(1):77-87
Pulmonary infectious diseases in patients with primary immunodeficiency and those treated with biologic immunomodulating agents.
Current opinion in pulmonary medicine. 2011;17(3):172-9