The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIX.b

Opportunistic pulmonary/systemic infections

Publications

Hendrick A

Fatal legionella pneumonia after fludarabine treatment in chronic lymphocytic leukaemia.

Journal of clinical pathology 2001 May;54;412-3 — 2001 May — 412-3

Anaissie EJ, Kontoyiannis DP, O'Brien S, Kantarjian H, Robertson L, Lerner S, Keating MJ

Infections in patients with chronic lymphocytic leukemia treated with fludarabine.

Annals of internal medicine 1998 Oct 01;129;559-66 — 1998 Oct 01 — 559-66