The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Publications

Schmutz JL, Barbaud A, Trechot P

[Aggravation of asthma by isotretinoine].

Annales de dermatologie et de venereologie 2001 May;128;691 — 2001 May — 691

Kapur N, Hughes JR, Rustin MH

Exacerbation of asthma by isotretinoin.

The British journal of dermatology 2000 Feb;142;388-9 — 2000 Feb — 388-9

Sabroe RA, Staughton RC, Bunker CB

Bronchospasm induced by isotretinoin.

BMJ (Clinical research ed.) 1996 Apr 06;312;886 — 1996 Apr 06 — 886

Fisher DA

Exercise-induced bronchoconstriction related to isotretinoin therapy.

Journal of the American Academy of Dermatology 1985 Sep;13;524 — 1985 Sep — 524