The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Subclinical ANA positivity
Publications
Adverse effects of acebutolol in chronic stable angina: drug-induced positive antinuclear antibody.
Journal of cardiovascular pharmacology 1984 Sep-Oct;6;735-8 — 1984 Sep-Oct — 735-8
Beta-adrenergic-receptor blockers and antinuclear antibodies in hypertension.
Clinical pharmacology and therapeutics 1982 May;31;555-8 — 1982 May — 555-8
Antinuclear antibodies in patients on acebutolol.
British journal of clinical pharmacology 1980 May;9;515-7 — 1980 May — 515-7