The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Varenika V, Blanc PD

A patient on RIPE therapy presenting with recurrent isoniazid-associated pleural effusions: a case report.

Journal of medical case reports 2011 Nov 30;5;558 — 2011 Nov 30 — 558

Khattri S, Kushawaha A, Dahal K, Lee M, Mobarakai N

Isoniazid (INH)-induced eosinophilic exudative pleural effusion and lupus erythematosus. A clinical reminder of drug side effects.

Bulletin of the NYU hospital for joint diseases 2011;69;181-4 — 2011 — 181-4

Hiraoka K, Nagata N, Kawajiri T, Suzuki K, Kurokawa S, Kido M, Sakamoto N

Paradoxical pleural response to antituberculous chemotherapy and isoniazid-induced lupus. Review and report of two cases.

Respiration; international review of thoracic diseases 1998;65;152-5 — 1998 — 152-5