The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Lee RE, Lotze MT, Skibber JM, Tucker E, Bonow RO, Ognibene FP, Carrasquillo JA, Shelhamer JH, Parrillo JE, Rosenberg SA

Cardiorespiratory effects of immunotherapy with interleukin-2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 Jan;7;7-20 — 1989 Jan — 7-20

Saxon RR, Klein JS, Bar MH, Blanc P, Gamsu G, Webb WR, Aronson FR

Pathogenesis of pulmonary edema during interleukin-2 therapy: correlation of chest radiographic and clinical findings in 54 patients.

AJR. American journal of roentgenology 1991 Feb;156;281-5 — 1991 Feb — 281-5

Vogelzang PJ, Bloom SM, Mier JW, Atkins MB

Chest roentgenographic abnormalities in IL-2 recipients. Incidence and correlation with clinical parameters.

Chest 1992 Mar;101;746-52 — 1992 Mar — 746-52

Morassut S, Balestreri L, Galligioni E, Coran F, Sacco C

[Radiologic characteristics of the thorax during therapy with interleukin-2].

La Radiologia medica 1992 Oct;84;368-71 — 1992 Oct — 368-71