The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Quan WD, Khan N, Ramirez M, Taylor WC, Quan F, Vinogradov M, Walker P

Correlation between development of pulmonary edema and response of pulmonary metastases of metastatic melanoma and kidney cancer to high-dose continuous-infusion interleukin-2.

Cancer biotherapy & radiopharmaceuticals 2005 Apr;20;151-4 — 2005 Apr — 151-4

Kammula US, White DE, Rosenberg SA

Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer.

Cancer 1998 Aug 15;83;797-805 — 1998 Aug 15 — 797-805

Fauroux B, Meyer-Milsztain A, Boccon-Gibod L, Leverger G, Clément A, Biour M, Tournier G

Cytotoxic drug-induced pulmonary disease in infants and children.

Pediatric pulmonology 1994 Dec;18;347-55 — 1994 Dec — 347-55

Glauser FL, DeBlois G, Bechard D, Fowler AA, Merchant R, Fairman RP

Cardiopulmonary toxicity of adoptive immunotherapy.

The American journal of the medical sciences 1988 Dec;296;406-12 — 1988 Dec — 406-12

Conant EF, Fox KR, Miller WT

Pulmonary edema as a complication of interleukin-2 therapy.

AJR. American journal of roentgenology 1989 Apr;152;749-52 — 1989 Apr — 749-52

Mann H, Ward JH, Samlowski WE

Vascular leak syndrome associated with interleukin-2: chest radiographic manifestations.

Radiology 1990 Jul;176;191-4 — 1990 Jul — 191-4

Saxon RR, Klein JS, Bar MH, Blanc P, Gamsu G, Webb WR, Aronson FR

Pathogenesis of pulmonary edema during interleukin-2 therapy: correlation of chest radiographic and clinical findings in 54 patients.

AJR. American journal of roentgenology 1991 Feb;156;281-5 — 1991 Feb — 281-5

Vogelzang PJ, Bloom SM, Mier JW, Atkins MB

Chest roentgenographic abnormalities in IL-2 recipients. Incidence and correlation with clinical parameters.

Chest 1992 Mar;101;746-52 — 1992 Mar — 746-52

Morassut S, Balestreri L, Galligioni E, Coran F, Sacco C

[Radiologic characteristics of the thorax during therapy with interleukin-2].

La Radiologia medica 1992 Oct;84;368-71 — 1992 Oct — 368-71