The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Quan WD Jr, Khan N, Ramirez M, Taylor WC, Quan F, Vinogradov M, Walker P

Correlation between development of pulmonary edema and response of pulmonary metastases of metastatic melanoma and kidney cancer to high-dose continuous-infusion interleukin-2.

Cancer biotherapy & radiopharmaceuticals. 2005;20(2):151-4

Kammula US, White DE, Rosenberg SA

Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer.

Cancer. 1998;83(4):797-805

Fauroux B, Meyer-Milsztain A, Boccon-Gibod L, Leverger G, Clément A, Biour M, Tournier G

Cytotoxic drug-induced pulmonary disease in infants and children.

Pediatric pulmonology. 1994;18(6):347-55

Glauser FL, DeBlois G, Bechard D, Fowler AA, Merchant R, Fairman RP

Cardiopulmonary toxicity of adoptive immunotherapy.

The American journal of the medical sciences. 1988;296(6):406-12

Conant EF, Fox KR, Miller WT

Pulmonary edema as a complication of interleukin-2 therapy.

AJR. American journal of roentgenology. 1989;152(4):749-52

Mann H, Ward JH, Samlowski WE

Vascular leak syndrome associated with interleukin-2: chest radiographic manifestations.

Radiology. 1990;176(1):191-4

Saxon RR, Klein JS, Bar MH, Blanc P, Gamsu G, Webb WR, Aronson FR

Pathogenesis of pulmonary edema during interleukin-2 therapy: correlation of chest radiographic and clinical findings in 54 patients.

AJR. American journal of roentgenology. 1991;156(2):281-5

Vogelzang PJ, Bloom SM, Mier JW, Atkins MB

Chest roentgenographic abnormalities in IL-2 recipients. Incidence and correlation with clinical parameters.

Chest. 1992;101(3):746-52

Morassut S, Balestreri L, Galligioni E, Coran F, Sacco C

[Radiologic characteristics of the thorax during therapy with interleukin-2].

La Radiologia medica. 1992;84(4):368-71