The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Publications

Ivanyi P, Fuehner T, Adam M, Eichelberg C, Herrmann E, Merseburger AS, Ganser A, Grünwald V

Interstitial lung disease during targeted therapy in metastatic renal cell carcinoma: a case series from three centres.

Medical oncology (Northwood, London, England) 2014 Sep;31;147 — 2014 Sep — 147

Boyle HJ, Chatté G, Rivoire M, Fléchon A

Lung toxicity in a patient treated with sunitinib.

The European respiratory journal 2012 Nov;40;1300-3 — 2012 Nov — 1300-3