The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.a

Methemoglobinemia

Publications

Eisenkraft JB

Pulse oximeter desaturation due to methemoglobinemia.

Anesthesiology. 1988;68(2):279-82

Pirmohamed M, Coleman MD, Hussain F, Breckenridge AM, Park BK

Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.

British journal of clinical pharmacology. 1991;32(3):303-10

Pounder RE, Craven ER, Henthorn JS, Bannatyne JM

Red cell abnormalities associated with sulphasalazine maintenance therapy for ulcerative colitis.

Gut. 1975;16(3):181-5