The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
Publications
Reversible lung fibrosis in a 6-year-old girl after long term nitrofurantoin treatment.
BMC pulmonary medicine. 2020;20(1):313
Browning ET, Huckleberry JM, Barrow WB, Restauri NL, Kemme DJ, Cool CD, Weyant MJ, Franklin WA, Camidge DR
Downstaging of Non-Small-Cell Lung Cancer Through Identification of Reversible Drug Toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016;34(2):e6-8
Nitrofurantoin-induced alterations in pulmonary tissue. A report on five patients with acute or subacute reactions.
Acta pathologica et microbiologica Scandinavica. Section A, Pathology. 1977;85(5):713-20