The Drug-Induced Respiratory Disease Website and App

BCG therapy (topical instillations in the urinary bladder)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.l

Systemic granulomatosis other than Xk

Publications

Higashioka K, Miyake N, Nishida R, Chong Y, Shimoda S, Shimono N

[Bilateral Granulomatous Renal Masses after Intravesical BCG Therapy for Non-muscle-invasive Bladder Cancer and Carcinoma in Situ of the Upper Urinary Tract: A Case Study].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2015;89(4):481-4

Delimpoura V, Samitas K, Vamvakaris I, Zervas E, Gaga M

Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy.

BMJ case reports. 2013;2013