The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.y

Subclinical ANA positivity

Publications

Blomgren SE, Condemi JJ, Bignall MC, Vaughan JH

Antinuclear antibody induced by procainamide. A prospective study.

The New England journal of medicine 1969 Jul 10;281;64-6 — 1969 Jul 10 — 64-6

Rubin RL, McNally EM, Nusinow SR, Robinson CA, Tan EM

IgG antibodies to the histone complex H2A-H2B characterize procainamide-induced lupus.

Clinical immunology and immunopathology 1985 Jul;36;49-59 — 1985 Jul — 49-59