The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.i

Flash (fulminate) pulmonary edema

May develop after first exposure to one single pill/tablet of drug

Publications

Traversa M, Collini A, Villois P, Elia F, Verhovez A, Aprà F

When a Diuretic Causes Pulmonary Oedema.

European journal of case reports in internal medicine. 2018;5(6):000864

Bernal C, Patarca R

Hydrochlorothiazide-induced pulmonary edema and associated immunologic changes.

The Annals of pharmacotherapy. 1999;33(2):172-4

Fine SR, Lodha A, Zoneraich S, Mollura JL

Hydrochlorothiazide-induced acute pulmonary edema.

The Annals of pharmacotherapy. 1995;29(7-8):701-3

Klein MD

Noncardiogenic pulmonary edema following hydrochlorothiazide ingestion.

Annals of emergency medicine. 1987;16(8):901-3

Caduff F, Gloor HJ

[Hydrochlorothiazide-induced lung edema with shock].

Schweizerische medizinische Wochenschrift. 1988;118(4):139-42

Bell RT, Lippmann M

Hydrochlorothiazide-induced pulmonary edema. Report of a case and review of the literature.

Archives of internal medicine. 1979;139(7):817-9