The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

Severe methemoglobinemia and hemolytic anemia from aniline purchased as 2C-E (4-ethyl-2,5-dimethoxyphenethylamine), a recreational drug, on the Internet - Oregon, 2011.

MMWR. Morbidity and mortality weekly report 2012 Feb 10;61;85-8 — 2012 Feb 10 — 85-8

Pizon AF, Schwartz AR, Shum LM, Rittenberger JC, Lower DR, Giannoutsos S, Virji MA, Krasowski MD

Toxicology laboratory analysis and human exposure to p-chloroaniline.

Clinical toxicology (Philadelphia, Pa.) 2009 Feb;47;132-6 — 2009 Feb — 132-6