The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Publications

Magee JS, Pittman LM, Jette-Kelly LA

Paradoxical Bronchoconstriction with Short-Acting Beta Agonist.

The American journal of case reports 2018 Oct 09;19;1204-1207 — 2018 Oct 09 — 1204-1207

Schissler AJ, Celli BR

Prevalence of paradoxical bronchoconstriction after inhaled albuterol.

Respiratory medicine 2018 08;141;100-102 — 2018 08 — 100-102

Wilkinson JR, Roberts JA, Bradding P, Holgate ST, Howarth PH

Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler.

BMJ (Clinical research ed.) 1992 Oct 17;305;931-2 — 1992 Oct 17 — 931-2