The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.i

Respiratory arrest - Apnea

Publications

Myint T, Evans ME, Burgess DR, Greenberg RN

Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs: A Case Report.

Journal of investigative medicine high impact case reports 2016 Jan-Mar;4;2324709616638362 — 2016 Jan-Mar — 2324709616638362

Wunsch H, Moitra VK, Patel M, Dzierba AL

Polymyxin use associated with respiratory arrest.

Chest 2012 Feb;141;515-517 — 2012 Feb — 515-517