The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.b

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Stricker BH, Ottervanger JP, van der Klauw MM

[Registration of suspected adverse effects by the Bureau Adverse Effects Drugs; research activities in 1993].

Nederlands tijdschrift voor geneeskunde 1994 Oct 15;138;2110-3 — 1994 Oct 15 — 2110-3

Eagle KA, Boucher CA

Intravenous dipyridamole infusion causes severe bronchospasm in asthmatic patients.

Chest 1989 Feb;95;258-9 — 1989 Feb — 258-9

Lette J, Cerino M, Laverdiere M, Tremblay J, Prenovault J

Severe bronchospasm followed by respiratory arrest during thallium-dipyridamole imaging.

Chest 1989 Jun;95;1345-7 — 1989 Jun — 1345-7