The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Derichs C, Klooster P, Vlasveld LT

A 66-year-old man with hydroxycarbamide induced pneumonitis.

The Netherlands journal of medicine 2018 Aug;76;298-301 — 2018 Aug — 298-301

Kamal P, Imran M, Irum A, Latham H, Magadan J

Hydroxyurea-Induced Interstitial Pneumonitis: A Rare Clinical Entity.

Kansas journal of medicine 2017 May;10;47-49 — 2017 May — 47-49

Girard A, Ricordel C, Poullot E, Claeyssen V, Decaux O, Desrues B, Delaval P, Jouneau S

[Hydroxyurea-induced pneumonia].

Revue des maladies respiratoires 2014 May;31;430-4 — 2014 May — 430-4

Internullo M, Giannelli V, Sardo L, Antonaglia C, Villani T, Angelici E, Palange P

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature.

European review for medical and pharmacological sciences 2014;18;190-3 — 2014 — 190-3

Doutrelon C, Lazaro E, Ribeiro E, Greib C, Pellegrin JL, Viallard JF

[Hydrocycarbamide induced fever: four cases and literature review].

La Revue de medecine interne 2015 Feb;36;73-7 — 2015 Feb — 73-7

Wong CC, Brown D, Howling SJ, Parker NE

Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure.

European journal of haematology 2003 Nov;71;388-90 — 2003 Nov — 388-90

Schwonzen M, Spangenberger H, Spengler M

[Hydroxyurea-induced pneumonitis].

Medizinische Klinik (Munich, Germany : 1983) 2003 Jul 15;98;394-7 — 2003 Jul 15 — 394-7

Sandhu HS, Barnes PJ, Hernandez P

Hydroxyurea-induced hypersensitivity pneumonitis: A case report and literature review.

Canadian respiratory journal 2000 Nov-Dec;7;491-5 — 2000 Nov-Dec — 491-5

Quintás-Cardama A, Pérez-Encinas M, Gonzalez S, Bendaña A, Bello JL

Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.

Annals of hematology 1999 Apr;78;187-8 — 1999 Apr — 187-8

Grace RF, Shenfield GM, Grant J, Ravich R

Recurrent pyrexia, cough and dyspnoea with hydroxyurea.

Australian and New Zealand journal of medicine 1998 Jun;28;347 — 1998 Jun — 347

Jackson GH, Wallis J, Ledingham J, Lennard A, Proctor SJ

Hydroxyurea-induced acute alveolitis in a patient with chronic myeloid leukaemia.

Cancer chemotherapy and pharmacology 1990;27;168-9 — 1990 — 168-9