The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.d

Pulmonary edema, cardiogenic

Publications

Abdelhalim AA, Mostafa M, Abdulmomen A, Othman EA

Severe hypertension and pulmonary edema associated with systemic absorption of topical phenylephrine in a child during retinal surgery.

Saudi journal of anaesthesia. 2012;6(3):285-8

Fischer Mde F, Moro ET, Guasti VM, Costa CT, Soeiro FS, Santos LC, Swensson Filho R

[Pulmonary edema after topic phenylephrine absorption during pediatric eye surgery: case report.].

Revista brasileira de anestesiologia. 2004;54(6):815-20

Fraunfelder FW, Fraunfelder FT, Jensvold B

Adverse systemic effects from pledgets of topical ocular phenylephrine 10%.

American journal of ophthalmology. 2002;134(4):624-5