The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Patients with HCT-induced pulmonary edema may present with hypotension, shock, leukopenia and hemoconcentration. Rare PE cases are from HCT-induced left ventricular failure
Publications
A Rare Case of Pulmonary Edema Secondary to Hydrochlorothiazide Use.
Case reports in critical care. 2024;2024:9423545
Hydrochlorothiazide-induced systemic capillary leak.
The American journal of emergency medicine. 2020;38(6):1299.e1-1299.e2
When a Diuretic Causes Pulmonary Oedema.
European journal of case reports in internal medicine. 2018;5(6):000864
[Severe and rare adverse reaction to hydrochlorothiazide].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993). 2018;65(4):442-445
Recurrent Hydrochlorothiazide-Induced Acute Respiratory Distress Syndrome Treated With Extracorporeal Membrane Oxygenation.
The Journal of emergency medicine. 2018;55(6):836-840
Hydrochlorothiazide-induced noncardiogenic pulmonary edema: BAL fluid analysis.
Chest. 2011;139(1):193-4
Hydrochlorothiazide-associated noncardiogenic pulmonary oedema and shock: a case report and review of the literature.
Acta cardiologica. 2007;62(2):215-20
Hydrochlorothiazide-induced noncardiogenic pulmonary edema: an underrecognized yet serious adverse drug reaction.
Pharmacotherapy. 2005;25(9):1258-65
Hydrochlorothiazide-induced pulmonary edema.
Southern medical journal. 1999;92(11):1100-2
Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema.
Lancet (London, England). 1996;348(9033):1035-6
Pulmonary oedema and hypotension induced by hydrochlorothiazide.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 1994;49(4):308-10
Hydrochlorothiazide-induced pulmonary edema with severe acute myocardial dysfunction.
Clinical cardiology. 1995;18(2):112-4
Acute idiosyncratic reaction to hydrochlorothiazide ingestion.
The Western journal of medicine. 1983;138(1):101-2
Pulmonary edemafolloing ingestion of hydrochlorothiazide.
JAMA. 1968;204(9):825-7
Non-cardiogenic pulmonary edema after oral ingestion of hydrochlorothiazide.
Intensive care medicine. 1987;13(5):364-5
Hydrochlorothiazide causing unexplained pulmonary oedema.
The British journal of clinical practice. 1989;43(2):79-81
Hydrochlorothiazide-associated pulmonary edema.
Chest. 1989;96(3):695-7
Non-cardiogenic pulmonary edema after ingestion of chlorothiazide.
BMJ (Clinical research ed.). 1989;298(6673):605
Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 1991;145(1):28-34