The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Watrigant Y, Wallaert B, Ramon P, Gosselin B, Peng W, Tonnel AB

[Subacute pneumopathy caused by hydrochlorothiazide. Cytologic study of the broncho-alveolar lavage].

Revue des maladies respiratoires 1986;3;227-9 — 1986 — 227-9

Biron P, Dessureault J, Napke E

Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991 Jul 01;145;28-34 — 1991 Jul 01 — 28-34