The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Kim J, Hoque F

Diffuse Alveolar Hemorrhage Linked to Hydralazine.

Journal of Brown hospital medicine 2024;3;32-35 — 2024 — 32-35

Acharya I, Weisman DS, Smith LW, Arend LJ

Diagnostic dilemma: drug-induced vasculitis versus systemic vasculitis.

BMJ case reports 2023 Jul 10;16; — 2023 Jul 10

Khosla AA, Saunders H, Helgeson S, Hikida H, Aslam N, Salem F, Albadri S, Baig H

The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.

Case reports in pulmonology 2023;2023;1461011 — 2023 — 1461011

Alawneh D, Edrees A

Hydralazine-Induced Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Case Report and Literature Review.

Cureus 2022 Apr;14;e24132 — 2022 Apr — e24132

Russe-Russe JR, Pellegrini JR, Alvarez-Betancourt A, Munshi RF, Anand P

Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.

Cureus 2021 Oct;13;e18974 — 2021 Oct — e18974

Battisha A, Doughem K, Sheikh O, Konduru L, Madoukh B, Al-Sadawi M, Shaikh S

Hydralazine-Induced ANCA Associated Vasculitis (AAV) Presenting with Pulmonary-Renal Syndrome (PRS): A Case Report with Literature Review.

Current cardiology reviews 2020 May 17;; — 2020 May 17

Al-Abdouh A, Siyal AM, Seid H, Bekele A, Garcia P

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.

Journal of medical case reports 2020 Apr 15;14;47 — 2020 Apr 15 — 47

Paley MA, Edrees F, Kudose S, Gaut JP, Ranganathan P, Vijayan A

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019 Jan-Feb;30;226-230 — 2019 Jan-Feb — 226-230

Kalra A, Yokogawa N, Raja H, Palaniswamy C, Desai P, Zanotti-Cavazzoni SL, Rajaram SS

Hydralazine-induced pulmonary-renal syndrome: a case report.

American journal of therapeutics 2012 Jul;19;e136-8 — 2012 Jul — e136-8