The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Kim J, Hoque F

Diffuse Alveolar Hemorrhage Linked to Hydralazine.

Journal of Brown hospital medicine. 2024;3(4):32-35

Acharya I, Weisman DS, Smith LW, Arend LJ

Diagnostic dilemma: drug-induced vasculitis versus systemic vasculitis.

BMJ case reports. 2023;16(7)

Khosla AA, Saunders H, Helgeson S, Hikida H, Aslam N, Salem F, Albadri S, Baig H

The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.

Case reports in pulmonology. 2023;2023:1461011

Alawneh D, Edrees A

Hydralazine-Induced Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Case Report and Literature Review.

Cureus. 2022;14(4):e24132

Russe-Russe JR, Pellegrini JR Jr, Alvarez-Betancourt A, Munshi RF, Anand P

Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.

Cureus. 2021;13(10):e18974

Doughem K, Battisha A, Sheikh O, Konduru L, Madoukh B, Al-Sadawi M, Shaikh S

Hydralazine-Induced ANCA Associated Vasculitis (AAV) Presenting with Pulmonary-Renal Syndrome (PRS): A Case Report with Literature Review.

Current cardiology reviews. 2021;17(2):182-187

Al-Abdouh A, Siyal AM, Seid H, Bekele A, Garcia P

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.

Journal of medical case reports. 2020;14(1):47

Paley MA, Edrees F, Kudose S, Gaut JP, Ranganathan P, Vijayan A

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2019;30(1):226-230

Kalra A, Yokogawa N, Raja H, Palaniswamy C, Desai P, Zanotti-Cavazzoni SL, Rajaram SS

Hydralazine-induced pulmonary-renal syndrome: a case report.

American journal of therapeutics. 2012;19(4):e136-8